Null Results in Brief No Association between Cytochrome P450 and Glutathione S-Transferase Gene Polymorphisms and Risk of Colorectal Adenoma: Results from the UK Flexible Sigmoidoscopy Screening Trial
نویسندگان
چکیده
Dunn Human Nutrition Unit, Medical Research Council, Cambridge, United Kingdom; Department of General Surgery, Norfolk and Norwich Health Care NHS Trust, Norwich, United Kingdom; Cancer Sciences Division, University of Southampton, Southampton, United Kingdom; Cancer Research UK Genetic Epidemiology Division, St James’s University Hospital, Leeds, United Kingdom; and Cancer Research UK, St Mark’s Hospital, Harrow, United Kingdom
منابع مشابه
No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial.
Dunn Human Nutrition Unit, Medical Research Council, Cambridge, United Kingdom; Department of General Surgery, Norfolk and Norwich Health Care NHS Trust, Norwich, United Kingdom; Cancer Sciences Division, University of Southampton, Southampton, United Kingdom; Cancer Research UK Genetic Epidemiology Division, St James’s University Hospital, Leeds, United Kingdom; and Cancer Research UK, St Mark...
متن کاملShort Communication GSTM1, GSTT1, and GSTP1 Polymorphisms and Risk of Advanced Colorectal Adenoma
Cigarette smoking is a risk factor for colon adenoma. The glutathione S-transferase enzymes are involved in the detoxification of carcinogenic compounds including those found in tobacco smoke, and thus, may be important modifiers of individual risk of developing this disease. We examined the prevalence of GSTM1 and GSTT1 gene deletions, and two GSTP1 polymorphisms in 772 cases with advanced col...
متن کاملبررسی پلیمورفیسم ژنی ایزوآنزیمهای GSTM1 و GSTP1 و فعالیت آنزیم گلوتاتیون S-ترانسفراز: مردان نابارور ایرانی
Background: Pi-GST and Mu-GST are subclasses of glutathione S-transferase that present on human sperm surface and play an important role against oxidative stress. Therefore, any defects in the enzyme activity may be associated with male infertility.In this study the polymorphisms of GSTM1 and GSTP1 in association with enzyme activity and sperm parameters were studied. Methods: This case-contro...
متن کاملGenetic polymorphisms of glutathione-s-transferase M1 and T1 genes with risk of diabetic retinopathy in Iranian population
Objective(s):To the best of our knowledge, this is the first report on the contributions of GST genetic variants to the risk of diabetic retinopathy in an Iranian population. Therefore, the objective of this study was to determine whether sequence variation in glutathione S-transferase gene (GSTM1 and GSTT1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (T2D...
متن کاملGSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma.
Cigarette smoking is a risk factor for colon adenoma. The glutathione S-transferase enzymes are involved in the detoxification of carcinogenic compounds including those found in tobacco smoke, and thus, may be important modifiers of individual risk of developing this disease. We examined the prevalence of GSTM1 and GSTT1 gene deletions, and two GSTP1 polymorphisms in 772 cases with advanced col...
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